Gender-Specific Modeling for Lassa Virus Transmission with Hearing Loss Disability Risk and Control Strategies

Authors

  • Kamel Guedri Mechanical Engineering Department, College of Engineering and Architecture, Umm Al-Qura University, P. O. Box 5555, Makkah 21955, Saudi Arabia
  • Yasir Ramzan Department of Mathematics, University of the Punjab, Lahore 54590, Pakistan
  • Muhammad Mudassar Bilal Department of Mathematics, University of the Punjab, Lahore 54590, Pakistan
  • Hatoon Abdullah Niyazi Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • Aziz Ullah Awan Department of Mathematics, University of the Punjab, Lahore 54590, Pakistan
  • Basim M. Makhdoum Mechanical Engineering Department, College of Engineering and Architecture, Umm Al-Qura University, P. O. Box 5555, Makkah 21955, Saudi Arabia

DOI:

https://doi.org/10.29020/nybg.ejpam.v18i2.6104

Keywords:

Lassa virus, Disability risk, Reproduction number, Parameter estimation, Sensitivity analysis, Optimal control

Abstract

This study examines the transmission with hearing loss disability risk of Lassa fever using a gender-spesific model based on nonlinear differential equations. The human population is divided into susceptible females, infected females, susceptible males, infected males, and recovered humans. Empirical data from LASV-endemic regions are employed for rigorous validation and parameter estimation, ensuring alignment with observed cases. The basic reproduction number \( R_0 \), obtained using the next-generation matrix approach, functions as a necessary limit to quantify outbreak prospects and evaluate control efficacy. Sensitivity analysis identifies dominant transmission drivers such as rodent-human contact rate. Analyzing optimal control techniques using Pontryagin's maximum principle, assess the impact of time-dependent interventions such as rodent population suppression and community-led hygiene education.

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Published

2025-05-01

Issue

Vol. 18 No. 2: (April 2025)

Section

Mathematical Biosciences

License

Copyright (c) 2025 Kamel Guedri, Yasir Ramzan, Muhammad Mudassar Bilal, Hatoon Abdullah Niyazi, Aziz Ullah Awan, Basim M. Makhdoum

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How to Cite

Gender-Specific Modeling for Lassa Virus Transmission with Hearing Loss Disability Risk and Control Strategies. (2025). European Journal of Pure and Applied Mathematics, 18(2), 6104. https://doi.org/10.29020/nybg.ejpam.v18i2.6104